AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system.
Identifieur interne : 000155 ( Main/Exploration ); précédent : 000154; suivant : 000156AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system.
Auteurs : Jingyue Jia [États-Unis] ; Bhawana Bissa [États-Unis] ; Lukas Brecht [Allemagne] ; Lee Allers [États-Unis] ; Seong Won Choi [États-Unis] ; Yuexi Gu [États-Unis] ; Mark Zbinden [États-Unis] ; Mark R. Burge [États-Unis] ; Graham Timmins [États-Unis] ; Kenneth Hallows [États-Unis] ; Christian Behrends [Allemagne] ; Vojo Deretic [États-Unis]Source :
- Autophagy [ 1554-8635 ] ; 2020.
Abstract
Lysosomal damage activates AMPK, a regulator of macroautophagy/autophagy and metabolism, and elicits a strong ubiquitination response. Here we show that the cytosolic lectin LGALS9 detects lysosomal membrane breach by binding to lumenal glycoepitopes, and directs both the ubiquitination response and AMPK activation. Proteomic analyses have revealed increased LGALS9 association with lysosomes, and concomitant changes in LGALS9 interactions with its newly identified partners that control ubiquitination-deubiquitination processes. An LGALS9-inetractor, deubiquitinase USP9X, dissociates from damaged lysosomes upon recognition of lumenal glycans by LGALS9. USP9X's departure from lysosomes promotes K63 ubiquitination and stimulation of MAP3K7/TAK1, an upstream kinase and activator of AMPK hitherto orphaned for a precise physiological function. Ubiquitin-activated MAP3K7/TAK1 controls AMPK specifically during lysosomal injury, caused by a spectrum of membrane-damaging or -permeabilizing agents, including silica crystals, the intracellular pathogen Mycobacterium tuberculosis, TNFSF10/TRAIL signaling, and the anti-diabetes drugs metformin. The LGALS9-ubiquitin system activating AMPK represents a novel signal transduction system contributing to various physiological outputs that are under the control of AMPK, including autophagy, MTOR, lysosomal maintenance and biogenesis, immunity, defense against microbes, and metabolic reprograming.
ABBREVIATIONS
AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; CAMKK2: calcium/calmodulin dependent protein kinase kinase 2; DUB: deubiquitinase; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K7/TAK1: mitogen-activated protein kinase kinase kinase 7; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; STK11/LKB1: serine/threonine kinase 11; TNFSF10/TRAIL: TNF superfamily member 10; USP9X: ubiquitin specific peptidase 9 X-linked.
DOI: 10.1080/15548627.2020.1788890
PubMed: 32597364
PubMed Central: PMC7469532
Affiliations:
- Allemagne, États-Unis
- Bavière, Californie, District de Haute-Bavière, Massachusetts, Nouveau-Mexique
- Munich
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Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Gu, Yuexi" sort="Gu, Yuexi" uniqKey="Gu Y" first="Yuexi" last="Gu">Yuexi Gu</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region 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Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32597364</idno><idno type="pmid">32597364</idno><idno type="doi">10.1080/15548627.2020.1788890</idno><idno type="pmc">PMC7469532</idno><idno type="wicri:Area/Main/Corpus">000056</idno><idno type="wicri:explorRef" wicri:stream="Main" 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type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Brecht, Lukas" sort="Brecht, Lukas" uniqKey="Brecht L" first="Lukas" last="Brecht">Lukas Brecht</name><affiliation wicri:level="3"><nlm:affiliation>Munich Cluster of Systems Neurology, Ludwig-Maximilians-Universität , München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Cluster of Systems Neurology, Ludwig-Maximilians-Universität , München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Allers, Lee" sort="Allers, Lee" uniqKey="Allers L" first="Lee" last="Allers">Lee Allers</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Choi, Seong Won" sort="Choi, Seong Won" uniqKey="Choi S" first="Seong Won" last="Choi">Seong Won Choi</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Gu, Yuexi" sort="Gu, Yuexi" uniqKey="Gu Y" first="Yuexi" last="Gu">Yuexi Gu</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Zbinden, Mark" sort="Zbinden, Mark" uniqKey="Zbinden M" first="Mark" last="Zbinden">Mark Zbinden</name><affiliation wicri:level="2"><nlm:affiliation>Human Metabolome Technologies America , Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Metabolome Technologies America , Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Burge, Mark R" sort="Burge, Mark R" uniqKey="Burge M" first="Mark R" last="Burge">Mark R. Burge</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of New Mexico School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of New Mexico School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Timmins, Graham" sort="Timmins, Graham" uniqKey="Timmins G" first="Graham" last="Timmins">Graham Timmins</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>School of Pharmacy, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Pharmacy, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Hallows, Kenneth" sort="Hallows, Kenneth" uniqKey="Hallows K" first="Kenneth" last="Hallows">Kenneth Hallows</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology and Hypertension, Department of Medicine and USC/UKRO Kidney Research Center, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology and Hypertension, Department of Medicine and USC/UKRO Kidney Research Center, Keck School of Medicine, University of Southern California , Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Behrends, Christian" sort="Behrends, Christian" uniqKey="Behrends C" first="Christian" last="Behrends">Christian Behrends</name><affiliation wicri:level="3"><nlm:affiliation>Munich Cluster of Systems Neurology, Ludwig-Maximilians-Universität , München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Cluster of Systems Neurology, Ludwig-Maximilians-Universität , München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="eISSN">1554-8635</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lysosomal damage activates AMPK, a regulator of macroautophagy/autophagy and metabolism, and elicits a strong ubiquitination response. Here we show that the cytosolic lectin LGALS9 detects lysosomal membrane breach by binding to lumenal glycoepitopes, and directs both the ubiquitination response and AMPK activation. Proteomic analyses have revealed increased LGALS9 association with lysosomes, and concomitant changes in LGALS9 interactions with its newly identified partners that control ubiquitination-deubiquitination processes. An LGALS9-inetractor, deubiquitinase USP9X, dissociates from damaged lysosomes upon recognition of lumenal glycans by LGALS9. USP9X's departure from lysosomes promotes K63 ubiquitination and stimulation of MAP3K7/TAK1, an upstream kinase and activator of AMPK hitherto orphaned for a precise physiological function. Ubiquitin-activated MAP3K7/TAK1 controls AMPK specifically during lysosomal injury, caused by a spectrum of membrane-damaging or -permeabilizing agents, including silica crystals, the intracellular pathogen <i>Mycobacterium tuberculosis</i>, TNFSF10/TRAIL signaling, and the anti-diabetes drugs metformin. The LGALS9-ubiquitin system activating AMPK represents a novel signal transduction system contributing to various physiological outputs that are under the control of AMPK, including autophagy, MTOR, lysosomal maintenance and biogenesis, immunity, defense against microbes, and metabolic reprograming.</div><div type="abstract" xml:lang="en"><p><b>ABBREVIATIONS</b></p><p>AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; CAMKK2: calcium/calmodulin dependent protein kinase kinase 2; DUB: deubiquitinase; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K7/TAK1: mitogen-activated protein kinase kinase kinase 7; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; STK11/LKB1: serine/threonine kinase 11; TNFSF10/TRAIL: TNF superfamily member 10; USP9X: ubiquitin specific peptidase 9 X-linked.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32597364</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-8635</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>08</Month></PubDate></JournalIssue><Title>Autophagy</Title><ISOAbbreviation>Autophagy</ISOAbbreviation></Journal><ArticleTitle>AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system.</ArticleTitle><Pagination><MedlinePgn>1550-1552</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/15548627.2020.1788890</ELocationID><Abstract><AbstractText>Lysosomal damage activates AMPK, a regulator of macroautophagy/autophagy and metabolism, and elicits a strong ubiquitination response. Here we show that the cytosolic lectin LGALS9 detects lysosomal membrane breach by binding to lumenal glycoepitopes, and directs both the ubiquitination response and AMPK activation. Proteomic analyses have revealed increased LGALS9 association with lysosomes, and concomitant changes in LGALS9 interactions with its newly identified partners that control ubiquitination-deubiquitination processes. An LGALS9-inetractor, deubiquitinase USP9X, dissociates from damaged lysosomes upon recognition of lumenal glycans by LGALS9. USP9X's departure from lysosomes promotes K63 ubiquitination and stimulation of MAP3K7/TAK1, an upstream kinase and activator of AMPK hitherto orphaned for a precise physiological function. Ubiquitin-activated MAP3K7/TAK1 controls AMPK specifically during lysosomal injury, caused by a spectrum of membrane-damaging or -permeabilizing agents, including silica crystals, the intracellular pathogen <i>Mycobacterium tuberculosis</i>, TNFSF10/TRAIL signaling, and the anti-diabetes drugs metformin. The LGALS9-ubiquitin system activating AMPK represents a novel signal transduction system contributing to various physiological outputs that are under the control of AMPK, including autophagy, MTOR, lysosomal maintenance and biogenesis, immunity, defense against microbes, and metabolic reprograming.</AbstractText><AbstractText Label="ABBREVIATIONS">AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; CAMKK2: calcium/calmodulin dependent protein kinase kinase 2; DUB: deubiquitinase; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K7/TAK1: mitogen-activated protein kinase kinase kinase 7; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; STK11/LKB1: serine/threonine kinase 11; TNFSF10/TRAIL: TNF superfamily member 10; USP9X: ubiquitin specific peptidase 9 X-linked.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Jingyue</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bissa</LastName><ForeName>Bhawana</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brecht</LastName><ForeName>Lukas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Munich Cluster of Systems Neurology, Ludwig-Maximilians-Universität , München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allers</LastName><ForeName>Lee</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Seong Won</ForeName><Initials>SW</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Yuexi</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0002-7234-1758</Identifier><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zbinden</LastName><ForeName>Mark</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-7741-9297</Identifier><AffiliationInfo><Affiliation>Human Metabolome Technologies America , Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burge</LastName><ForeName>Mark R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, University of New Mexico School of Medicine , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Timmins</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Pharmacy, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hallows</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Nephrology and Hypertension, Department of Medicine and USC/UKRO Kidney Research Center, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Behrends</LastName><ForeName>Christian</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-9184-7607</Identifier><AffiliationInfo><Affiliation>Munich Cluster of Systems Neurology, Ludwig-Maximilians-Universität , München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deretic</LastName><ForeName>Vojo</ForeName><Initials>V</Initials><Identifier Source="ORCID">0000-0002-3624-5208</Identifier><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health School of Medicine , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P20 GM121176</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI111935</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AI042999</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Autophagy</MedlineTA><NlmUniqueID>101265188</NlmUniqueID><ISSNLinking>1554-8627</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y"> Mycobacterium tuberculosis </Keyword><Keyword MajorTopicYN="Y">AMPK</Keyword><Keyword MajorTopicYN="Y">TAK1</Keyword><Keyword MajorTopicYN="Y">TRAIL</Keyword><Keyword MajorTopicYN="Y">USP9X</Keyword><Keyword MajorTopicYN="Y">autophagy</Keyword><Keyword MajorTopicYN="Y">diabetes</Keyword><Keyword MajorTopicYN="Y">lysosome</Keyword><Keyword MajorTopicYN="Y">metabolism</Keyword><Keyword MajorTopicYN="Y">metformin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>07</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32597364</ArticleId><ArticleId IdType="doi">10.1080/15548627.2020.1788890</ArticleId><ArticleId IdType="pmc">PMC7469532</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Mol Cell. 2020 Mar 5;77(5):951-969.e9</Citation><ArticleIdList><ArticleId IdType="pubmed">31995728</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Bavière</li><li>Californie</li><li>District de Haute-Bavière</li><li>Massachusetts</li><li>Nouveau-Mexique</li></region><settlement><li>Munich</li></settlement></list><tree><country name="États-Unis"><region name="Nouveau-Mexique"><name sortKey="Jia, Jingyue" sort="Jia, Jingyue" uniqKey="Jia J" first="Jingyue" last="Jia">Jingyue Jia</name></region><name sortKey="Allers, Lee" sort="Allers, Lee" uniqKey="Allers L" first="Lee" last="Allers">Lee Allers</name><name sortKey="Allers, Lee" sort="Allers, Lee" uniqKey="Allers L" first="Lee" last="Allers">Lee Allers</name><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><name sortKey="Burge, Mark R" sort="Burge, Mark R" uniqKey="Burge M" first="Mark R" last="Burge">Mark R. Burge</name><name sortKey="Burge, Mark R" sort="Burge, Mark R" uniqKey="Burge M" first="Mark R" last="Burge">Mark R. Burge</name><name sortKey="Choi, Seong Won" sort="Choi, Seong Won" uniqKey="Choi S" first="Seong Won" last="Choi">Seong Won Choi</name><name sortKey="Choi, Seong Won" sort="Choi, Seong Won" uniqKey="Choi S" first="Seong Won" last="Choi">Seong Won Choi</name><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><name sortKey="Gu, Yuexi" sort="Gu, Yuexi" uniqKey="Gu Y" first="Yuexi" last="Gu">Yuexi Gu</name><name sortKey="Gu, Yuexi" sort="Gu, Yuexi" uniqKey="Gu Y" first="Yuexi" last="Gu">Yuexi Gu</name><name sortKey="Hallows, Kenneth" sort="Hallows, Kenneth" uniqKey="Hallows K" first="Kenneth" last="Hallows">Kenneth Hallows</name><name sortKey="Jia, Jingyue" sort="Jia, Jingyue" uniqKey="Jia J" first="Jingyue" last="Jia">Jingyue Jia</name><name sortKey="Timmins, Graham" sort="Timmins, Graham" uniqKey="Timmins G" first="Graham" last="Timmins">Graham Timmins</name><name sortKey="Timmins, Graham" sort="Timmins, Graham" uniqKey="Timmins G" first="Graham" last="Timmins">Graham Timmins</name><name sortKey="Zbinden, Mark" sort="Zbinden, Mark" uniqKey="Zbinden M" first="Mark" last="Zbinden">Mark Zbinden</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Brecht, Lukas" sort="Brecht, Lukas" uniqKey="Brecht L" first="Lukas" last="Brecht">Lukas Brecht</name></region><name sortKey="Behrends, Christian" sort="Behrends, Christian" uniqKey="Behrends C" first="Christian" last="Behrends">Christian Behrends</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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